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Filtered Search Results
Medchemexpress LLC Sulfo Cy7 tyramide | 99.1% | 802.01 | C43H51N3O8S2 | 10 MG
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Sulfo Cy7 tyramide is a near-infrared fluorescent tyramide reagent (Ex = 740 nm, Em = 770 nm) used as the reporter substrate for horseradish peroxidase (HRP)-catalyzed deposition in tyramide signal amplification (TSA). It is supplied as a solid with demonstrated high purity and is intended for fluorescence-based detection, including multiplex immunohistochemistry.
- Near-infrared excitation/emission: 740/770 nm.
- High purity (LCMS: 99.13%).
- Compatible with HRP-based tyramide signal amplification and multiplex IHC.
- Soluble in DMSO at 12.5 mg/mL (requires ultrasonic).
- Store protected from light at 4°C; in solvent: -80°C (6 months) or -20°C (1 month).
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Apexbio Technology LLC Palifosfamide 31645-39-3 200mg
Palifosfamide (CAS 31645-39-3) is the active metabolite derivative of ifosfamide (IFA) an alkylating agent exhibiting cytotoxic effects through cross-linking DNA strands thereby interfering with replication and transcription Palifosfamide lysine demonstrates anticancer activity against pediatric sarcoma cell lines including osteosarcoma models such as SAOS-2 (IC50 2 25 6 75 M) and decreased sensitivity in OS222 (IC50 31 5 M) In murine xenograft experiments (MX-1 tumors) palifosfamide treatment at 100 mg/kg showed substantial tumor growth inhibition ( 80%) and partial complete response rates ( 17%) highlighting its applicability in preclinical oncology research
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Apexbio Technology LLC Torin 2 1223001-51-1 200mg
Torin 2 (CAS 1223001-51-1) is a selective orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) exhibiting an EC50 of approximately 0 25 nM Structurally improved from Torin 1 Torin 2 interacts via hydrogen bonding with residues V2240 and Y2225 in mTOR and two additional interactions between its aniline amino group and residues D2195 and D2357 enhancing potency and pharmacokinetic properties It displays high selectivity for mTOR over phosphoinositide 3-kinases (PI3Ks) and other protein kinases by nearly 800-fold Due to these properties Torin 2 is extensively studied in oncological research targeting mTOR signaling pathways
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Medchemexpress LLC KNK437 | 218924-25-5 | 99.0% | 245.23 g/mol | C13H11NO4 | 200 MG
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KNK437 is a small-molecule heat shock protein (HSP) inhibitor that suppresses the induction of HSP105, HSP70, and HSP40. Provided as a light-yellow solid for research use, it is reported to have high purity and defined molecular weight, making it suitable for biochemical and cell-based studies of stress response and chaperone pathways.
- Inhibits induction of HSP105, HSP70, and HSP40.
- High purity suitable for biochemical and cell-based assays.
- Available in multiple pack sizes for experimental flexibility.
- Light-yellow solid form for standard laboratory handling.
- Stable when stored under recommended temperature conditions.
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Medchemexpress LLC Sulfo-N-succinimidyl 4-maleimidobutyrate sodium salt | 185332-92-7 | MFCD17215919 | 98.8% | 382.28 g/mol | C12H11N2NaO9S | 1 ML
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Sulfo-GMBS is a water-soluble, heterobifunctional cross-linker that links primary amines to sulfhydryl groups via a non-cleavable maleimide spacer. Supplied as a ready-to-use 10 mM solution in DMSO or as a solid, it is intended for protein and peptide conjugation, immobilization, and labeling in biochemical and assay workflows.
- Water-soluble amine-thiol cross-linker suitable for protein and peptide conjugation.
- Provides a short, non-cleavable spacer facilitating stable linkage between functional groups.
- Available as a 10 mM solution in DMSO or in solid form for flexible use.
- High purity (approximately 98.8%) supports reproducible conjugation reactions.
- Soluble in DMSO at 50 mg/mL (≈130.8 mM) for easy preparation of working solutions.
- Recommended storage: solid at -20°C sealed; in solvent at -80°C for extended stability.
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Apexbio Technology LLC Acetosyringone 2478-38-8 200mg
Acetosyringone is a phenolic small molecule that interacts with the Agrobacterium tumefaciens virulence (vir) regulatory system It functions by activating the membrane-bound kinase encoded by the virA gene initiating autophosphorylation events and subsequent activation of the virG transcriptional regulator which induces expression of additional virulence genes Acetosyringone exerts its biological activity primarily through the activation of the VirA/VirG two-component system Based on these properties acetosyringone is widely used in plant biotechnology for enhancing Agrobacterium-mediated transformation and genetic engineering studies in various plant species and algae
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Apexbio Technology LLC Anastrozole 120511-73-1 200mg
Anastrozole (CAS 120511-73-1) is a selective non-steroidal aromatase inhibitor that suppresses estrogen biosynthesis by inhibiting the aromatase enzyme In in vitro assays using human placental aromatase anastrozole demonstrated an IC50 of 14 6 nM (0 0043 g/ml) Oral administration at 0 1 mg/kg completely inhibited ovulation in preclinical models and eliminated exogenous androgen-induced uterotrophic activity in juvenile rodents Additionally it has been shown to inhibit the conversion of 11-deoxycortisol to cortisol in guinea pig dog and bovine adrenal microsomes with IC50 values of 4 09 M 129 M and 11 9 M respectively Anastrozole is widely used in research to study estrogen-mediated pathways and endocrine modulation
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Medchemexpress LLC Mocetinostat | 726169-73-9 | >98.0% | 200 MG
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Mocetinostat is a benzamide histone deacetylase (HDAC) inhibitor selective for class I/IV HDACs, used as a research compound in epigenetics and oncology studies. Typical potency: HDAC1 0.15 μM; HDAC2 0.29 μM; HDAC3 1.66 μM; HDAC11 0.59 μM. For research use only.
- Selective class I/IV HDAC inhibitor.
- Used in epigenetics and cancer research.
- Typical purity >98% (supplier dependent).
- Molecular formula C23H20N6O; molecular weight ≈396.4 g/mol.
- Supplied as a 200 mg research pack.
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000283981 6-O-SULFO--CYCLODEX 10MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000284621 6-O-SULFO--CYCLODEX 5MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000291328 B7-H2/ICOSLG RAT H 5UG
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Medchemexpress LLC Liproxstatin-1 | 950455-15-9 | 99.70% | 200 MG
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Liproxstatin-1 is identified as a potent ferroptosis inhibitor, effectively suppressing ferroptotic cell death with an IC50 value of 22 nM. It demonstrates anti-ferroptotic activity across various cell types, including fibroblasts, lymphocytes, and mouse embryonic fibroblasts (MEFs). Studies have also indicated its ability to suppress ferroptosis in vivo, specifically in human cells, Gpx4 deficient kidney cells, and in an ischemia/reperfusion-induced tissue injury model.
- Potent ferroptosis inhibitor.
- Inhibits ferroptotic cell death with an IC50 of 22 nM.
- Shows anti-ferroptotic activity in mouse embryonic fibroblasts with an IC50 of approximately 38 nM.
- Suppresses ferroptosis in human cells.
- Suppresses ferroptosis in Gpx4 deficient kidney.
- Suppresses ferroptosis in an ischemia/reperfusion-induced tissue injury model.
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Medchemexpress LLC EGFR-IN-86 | 3055550-22-3 | 99.9% | 423.49 | 5 MG
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EGFR-IN-86 is an epidermal growth factor receptor (EGFR) inhibitor, characterized by its high activity against glioblastoma with an IC50 of 1.5 nM. This compound has demonstrated the ability to induce apoptosis and arrest the U87 cell cycle in the G2/M phase, indicating its potential as an anti-glioma agent.
- Acts as an EGFR inhibitor with high potency.
- Exhibits significant activity against glioblastoma.
- Induces apoptosis in cells.
- Arrests the U87 cell cycle in the G2/M phase.
- Available in solid form, with a white to off-white appearance.
- Purity of 99.92% ensures high quality for research applications.
- Easily soluble in DMSO for in vitro studies.
- Can be prepared for in vivo experiments using specific solvent protocols to ensure reliable results.
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Medchemexpress LLC EPACADOSTAT 200 mg
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EPACADOSTAT 200MG
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Medchemexpress LLC LEUKADHERIN-1 200 mg
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LEUKADHERIN-1 200MG
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