Quinolines and derivatives

Medchemexpress LLC Amino-PEG5-amine | 72236-26-1 | 97.0% | 5 G

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Amino-PEG5-amine is a PEG-based (5 units) PROTAC linker, appearing as a colorless to light yellow liquid. With a molecular weight of 280.36 and a formula of C12H28N2O5, it is soluble in water (≥ 100 mg/mL). This compound is suitable for research use only.

• Used in the synthesis of PROTACs
• Appears as a colorless to light yellow liquid
• Soluble in water (≥ 100 mg/mL)
• For research use only

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Selleck Chemical LLC Cell Counting Kit-8 B34304-25ML

The Bimake Cell Counting Kit-8 (CCK-8) is a fluorescent assay for the determination of cell viability in vitro Results are obtained in only 3 steps addition incubation and reading

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Medchemexpress LLC MEDCHEMEXPRESS LLC

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5000266535 EDOXABAN IMPURITY 59 25MG

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Medchemexpress LLC 1H-Imidazole-2-carbaldehyde | 10111-08-7 | MFCD00003544 | 96.09 | 10 G

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1H-Imidazole-2-carbaldehyde is a biochemical reagent suitable for life science research as a biological material or organic compound. This compound acts as a novel protein tyrosine phosphatase 1B (PTP1B) inhibitor with potential applications in suppressing type-2 diabetes.

• Can be used as a biological material or organic compound for life science related research.
• Acts as a novel protein tyrosine phosphatase 1B (PTP1B) inhibitor.
• Has potential application to suppress type-2 diabetes.
• Used in the preparation of tridentate Schiff-base carboxylate-containing ligands by condensation reaction with amino acids.
• Involved in the study of imidazole-directed allylation of aldimines.

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eMolecules​ 8-CHLORONAPHTHALEN-1-AMINE 1G

5000188282 8-CHLORONAPHTHALEN-1-AMINE 1G

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Medchemexpress LLC Methotrexate metabolite | 19741-14-1 | MFCD00075774 | 98.4% | 325.33 g/mol | C15H15N7O2 | 200 MG

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Methotrexate metabolite (DAMPA) is the primary active metabolite of methotrexate, supplied as an analytical standard for laboratory research, pharmacokinetic, and metabolism studies. It is intended for use as a reference standard in analytical assays and for investigation of methotrexate metabolism and clearance.

• Active metabolite of methotrexate used as an analytical standard.
• Suitable for pharmacokinetic and metabolism research.
• Molecular formula C15H15N7O2.
• Molecular weight 325.33 g/mol.
• Purity 98.4% (HPLC).
• Supplied as a solid for laboratory use.
• Not for human or veterinary use.

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Medchemexpress LLC CP 339818 hydrochloride | 478341-55-8 | 99.6% | 340.89 g/mol | C21H25ClN2 | 5 MG

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CP 339818 hydrochloride is a small-molecule, non-peptide ion-channel inhibitor used in electrophysiology and pharmacology research. It blocks Kv1.3 and Kv1.4 channels and inhibits HCN channels, making it useful for studying Kv- and HCN-mediated currents and T-cell activation.

• Non-peptide Kv1.3 and Kv1.4 channel blocker.
• Inhibits HCN channel isoforms with micromolar potency.
• High-purity white to off-white solid suitable for research use.
• Soluble in DMSO up to 62.5 mg/mL.
• Store sealed at 4°C; in solution, keep at -80°C (up to 6 months) or -20°C (up to 1 month).
• Molecular weight 340.89 g/mol; formula C21H25ClN2.

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Medchemexpress LLC 3-[2,4-dimethyl-5-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid | 252916-29-3 | MFCD09743433 | >98.0% | 310.3 g/mol | C18H18N2O3 | 200 MG

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Orantinib is a small-molecule, orally bioavailable receptor tyrosine kinase inhibitor that selectively inhibits VEGFR2, PDGFRβ, and FGFR1, blocking receptor autophosphorylation and angiogenesis. It is used in preclinical and clinical research for tumor growth inhibition and antiangiogenic studies. Chemical formula C18H18N2O3; molecular weight ~310.3 g/mol; CAS 252916-29-3.

• Multi-target inhibition of VEGFR2, PDGFRβ, and FGFR1.
• Orally bioavailable small molecule suitable for in vivo and in vitro studies.
• Blocks receptor autophosphorylation and inhibits angiogenesis.
• Applied in oncology and angiogenesis research applications.
• High purity material appropriate for research use.

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Medchemexpress LLC 1-(4-(aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine dihydrochloride | 1620278-72-9 | MFCD31657341 | 99.7% | 432.39 g/mol | C22H27Cl2N5 | 1 ML

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TLR7/8 agonist 1 dihydrochloride is a dual-agonistic imidazoquinoline research compound that activates toll-like receptors 7 and 8 to induce innate immune responses. It is used in cell-based assays and in vivo studies to stimulate immune signaling and can serve as a derivatizable precursor for covalent labeling while retaining biological activity.

• Dual agonist of toll-like receptors 7 and 8, inducing innate immune signaling.
• Low-nanomolar agonistic potency (≈50 nM for TLR7, ≈55 nM for TLR8).
• Available as a DMSO solution for convenient dosing in cell assays.
• Suitable for use in cell-based and in vivo immunostimulatory studies.
• Precursor amenable to covalent modification without significant loss of activity.
• Stable when stored sealed at 4°C; in solution recommended -80°C for long-term storage.

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